The Inhibitory Effect of Eupatilin on the Agonist-Induced Regulation of Vascular Contractility
The Korean Journal of Physiology and Pharmacology
; : 31-36, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-728175
Biblioteca responsável:
WPRO
ABSTRACT
The present study was undertaken to investigate the influence of eupatilin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Eupatilin more significantly relaxed fluoride-induced vascular contraction than thromboxane A2 or phorbol ester-induced contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, eupatilin significantly inhibited fluoride-induced increases in pMYPT1 levels. On the other hand, it didn't significantly inhibit phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving the primarily inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1. This study provides evidence regarding the mechanism underlying the relaxation effect of eupatilin on agonist-induced vascular contraction regardless of endothelial function.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Relaxamento
/
Tromboxano A2
/
Vasodilatação
/
Flavonoides
/
Forbóis
/
Contratos
/
Quinases Associadas a rho
/
Mãos
/
Contração Isométrica
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2013
Tipo de documento:
Artigo