Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
The Korean Journal of Physiology and Pharmacology
; : 9-13, 2013.
Article
em En
| WPRIM
| ID: wpr-728178
Biblioteca responsável:
WPRO
ABSTRACT
The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Perfusão
/
Permeabilidade
/
Fosfatidilcolinas
/
Dodecilsulfato de Sódio
/
Naftoquinonas
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Ácido Desoxicólico
/
Absorção
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Absorção Intestinal
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Intestino Grosso
/
Micelas
Limite:
Animals
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2013
Tipo de documento:
Article