Effect of Korean Red Ginseng on Testicular Tissue Injury after Torsion and Detorsion
Korean Journal of Urology
; : 794-799, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-7287
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Korean red ginseng (KRG) is a potent antioxidant and a free radical scavenger. This study was designed to determine whether KRG could protect against dysfunction and oxidative stress induced by torsion-detorsion injury in rat testis. MATERIALS ANDMETHODS:
Six-week-old male Sprague-Dawley rats were randomly divided into four groups a sham-operated control group (C), a sham-operated and KRG-treated group (K), a 2 hours torsion and detorsion group (T), and a 2 hours torsion and detorsion and KRG-treated group (T+K). We measured testis weight and hormone levels and reactive oxygen species (ROS) from the left renal vein. Superoxide generation was measured on the basis of lucigenin-enhanced chemiluminescence in testis tissue.RESULTS:
Testicular weight was significantly higher in the T+K group than in the T group; however, there were no significant differences in hormone levels between the 4 groups. The mean level of ROS and superoxide production was significantly higher in the T group than in the C group, whereas administration of KRG attenuated this increase. Upon histologic evaluation, the T group was found to have cellular disarray, a lack of cellular cohesiveness, degenerative changes in the germinal cells, and less distinct changes in the seminiferous tubules, whereas the T+K group had a germinal epithelial layer that appeared nearly normal.CONCLUSIONS:
The present study demonstrated that KRG recovered the testis dysfunction in the rat testis by suppressing superoxide production.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Veias Renais
/
Túbulos Seminíferos
/
Torção do Cordão Espermático
/
Testículo
/
Espécies Reativas de Oxigênio
/
Ratos Sprague-Dawley
/
Superóxidos
/
Estresse Oxidativo
/
Luminescência
/
Panax
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Urology
Ano de publicação:
2010
Tipo de documento:
Artigo