A literature Review Study on Kawasaki Disease with Special Concern on Causal Hypothesis / 한국역학회지
Korean Journal of Epidemiology
; : 288-318, 1998.
Article
em Ko
| WPRIM
| ID: wpr-728978
Biblioteca responsável:
WPRO
ABSTRACT
Kawasaki disease that had been identified and reported as a new syndrome complex by a Japanese pediatrician Kawasaki in 1967 still remains as a disease of unknown etiology despite the enormous research efforts throughout the world. We conducted this literature review study with an attempt to formulate causal gypothesis on Kawasaki disease based on research findings published. Summarizing the research results in terms of clinical, pathologic and epidemiologic characteristics we could characterize the causative agent as followings: (1) The agent should have high infectivity and low pathogenicity causing generalized infection, perhaps with more frequent inapparent infection than apparent infection, particularly among immunocompromized, feeble children by preceded infection, (2) The target organ of the agent seems to be endothelial cells of arteries, (3) The agent appears to take airborne transmission route in very special environment where the agent can be supplied by reservoirs other than human beings, and (4) the agent should be quite ubiquitous around human living environment resulting in high herd immunity among adult population. For the time being we propose Coxiella burneti as a possible causative agent that could satisfy the most of the above characteristics.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Artérias
/
Virulência
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Coxiella
/
Imunidade Coletiva
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Células Endoteliais
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Povo Asiático
/
Síndrome de Linfonodos Mucocutâneos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Child
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Epidemiology
Ano de publicação:
1998
Tipo de documento:
Article