Wnt/β-catenin signaling pathway and gastric cancer / 国际外科学杂志

ABSTRACT

Wnt/β-catenin signaling pathway is an evolutionarily conserved signaling pathway that plays an important role in embryonic and organ development,which is not only invovled in regulating several cellular proliferation,differentiation,polarity,migration and apoptosis,but aslo playing an critical role in initiation,invasion,metastasis,progression and drug resistance of gastric cancer.This article will review the newest studies about gastric cancer of Wnt/β-catenin and provide fundamenal theories to design new drugs for the treatment of gastric cancer.