Study on lipid and protein metabolism status of preterm infants whose mothers suffered from pregnancy induced hypertension / 中华实用儿科临床杂志

ABSTRACT

Objective To investigate the lipid and protein metabolism status of preterm infants whose mothers suffered from pregnancy induced hypertension.Methods One hundred and nineteen premature neonates in accordance with inclusion criteria,who were admitted to the Department of Pediatrics,Peking University People's Hospital from Jan.2010 to Dec.2011,were chosen as study samples.The preterm infants were divided into 2 groups,that was mothers with pregnancy induced hypertension group (observation group) and mothers without pregnancy complications group (control group).Then the general condition as well as the lipid and protein levels,which were tested within 24 h after birth,and which of preterm newborns in 2 groups were compared.Results The percent of 26.5 of the preterm infants in observation group were small for gestational age,while the ratio was 11.8％ for ones in control group,there was significant difference (P ＜ 0.05).The rate of fetal distress and neonatal asphyxia was 29.4％ in observation group,however,the ratio was 12.9％ for ones in control group,there was significant difference (P ＜ 0.05).The levels of low density lipoprotein [(1.20 ± 0.66) mmol/L],cholesterol [(2.80 ± 1.07) mmol/L] and total protein [(51.51 ± 6.88) mmol/L] in observation group were higher than those [(0.88 ± 0.37) mmol/L,(2.26 ± 0.66) mmol/L,(48.66 ±6.86) mmol/L] of ones in control group(all P ＜0.05,0.01).However,there were no significant difference of the levels of high density lipoprotein[(0.86 ± 0.26)mmol/L vs (0.82 ± 0.24) mmol/L],triglyceride [(0.29 ± 0.15)mmol/L vs (0.27 ±0.18) mmol/L] and albumin[(34.63 ±3.33) mmol/L vs (33.13 ±5.64) mmol/L] between the 2 groups(all P ＞0.05).Conclusions Mothers with pregnancy induced hypertension can affect the intrauterine growth,levels of lipid and total protein of their offsprings.At the same time,it also increases the possibility of perinatal hypoxia.