Correlation among high sensitivity C reactive protein,inflammatory factor levels and cardiac function in patients with dilated cardiomyopathy / 心血管康复医学杂志

ABSTRACT

Objective:To explore correlation among high sensitivity C reactive protein (hsCRP),inflammatory factor levels and cardiac function in patients with dilated cardiomyopathy (DCM).Methods:A total of 102 DCM patients were continu-ously collected in our hospital from Mar 2014 to Mar 2016.According to their hsCRP level at hospitalization,patients were divided into low hsCRP group (n＝51,≤3mg/L) and high hsCRP group (n＝51,＞3mg/L).Levels of hsCRP,brain na-triuretic peptide (BNP),interleukin (IL)-6,IL-1 and tumor necrosis factor (TNF)-α,left ventricular end-diastolic di-mension (LVEDd) and left ventricular ejection fraction (LVEF) were measured and compared between two groups.Corre-lation between inflammatory factors and cardiac function indexes were analyzed.Results:Compared with low hsCRP group [ (2.18 ± 0.12) mg/L],there were significant rise in LVEDd [ (58.47 ± 6.16) mm vs.(66.58 ± 9.45) mm],levels of BNP [(232.04 ± 56.07) pg/ml vs.(466.34 ± 105.12) pg/ml],IL-6 [(6.48 ± 2.48) ng/L vs.(9.38 ± 2.41) ng/L],IL-1 [(63.58 ± 6.58) ng/L vs.(67.84 ± 5.75) ng/L] and TNF-α [(74.58 ± 8.39) ng/L vs.(79.58 ± 10.71) ng/L],and significant reduction in LVEF [ (38.67 ± 6.08)% vs.(33.23 ± 5.15)%] in high hsCRP group [ (3.87 ± 1.53) mg/L],P＜0.05 or ＜0.01.Linear correlation analysis indicated that in high hsCRP patients,hsCRP level was significant positive-ly correlated with levels of IL-6,IL-1 and TNF-α ( r＝0.328～0.341,P＜0.05 all);levels of hsCRP,IL-6,IL-1 and TNF-α were significant positively correlated with BNP level,LVEDd and NYHA class (r＝0.241～0.432,P＜0.05 or ＜0.01),and significant inversely correlated with LVEF (r＝ -0.346～ -0.327,P＜0.05 all).Conclusion:High sensitivity C reactive protein level is significantly correlated with cardiac function in DCM patients.Therefore,it can be used as an important index monitoring cardiac function changes in these patients.