Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
; : 5-2018.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-741575
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo.METHODS:
Eleven Sprague-Dawley rats were used, and BTX-A (n = 6) or saline (n = 5) was injected at 13 days of age. All injections were given to the right masseter muscle, and the BTX-A dose was 0.5 units. All of the rats were euthanized at 60 days of age. The skulls of the rats were separated and fixed with 10% formalin for micro-computed tomography (micro-CT) analysis.RESULTS:
The anthropometric analysis found that the ramus heights and bigonial widths of the BTX-A-injected group were significantly smaller than those of the saline-injected group (P < 0.05), and the mandibular plane angle of the BTX-A-injected group was significantly greater than in the saline-injected group (P < 0.001). In the BTX-A-injected group, the ramus heights II and III and the mandibular plane angles I and II showed significant differences between the injected and non-injected sides (P < 0.05). The BTX-A-injected side of the mandible in the masseter group showed significantly lower mandibular bone growth compared with the non-injected side.CONCLUSION:
BTX-A injection into the masseter muscle influences mandibular bone growth.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Crânio
/
Desenvolvimento Ósseo
/
Toxinas Botulínicas
/
Ratos Sprague-Dawley
/
Toxinas Botulínicas Tipo A
/
Formaldeído
/
Mandíbula
/
Músculo Masseter
/
Músculos da Mastigação
Limite:
Animais
Idioma:
Inglês
Revista:
Maxillofacial Plastic and Reconstructive Surgery
Ano de publicação:
2018
Tipo de documento:
Artigo