Investigation on antimicrobial usage in 451 patients with complicated intra-abdominal infection / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
; (12): 609-613, 2019.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-743276
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the microbiological epidemiology and clinical use of antibiotics in patients complicated intra-abdominal infection (cIAI),therefore to optimize antibiotic use and to promote antimicrobial stewardship.Methods A total of 451 patients with cIAI from a Chinese tertiary hospital between January 2015 and December 2016 were retrospectively reviewed.The infection severity,timing of microbiological specimen sampling,culture results,initial antibiotic selection and later anti-infective regimen adjustment were analyzed.Results Three hundred and sixteen (70.1%,316/451) patients undergone microbiological investigation at infection sites within 3 days and 133 (42.1%) patients had a positive culture,of which 64.5% were Enterobacteriaceae.Three hundred seventy-four patients (82.9%) initially received broad-spectrum antibiotics against gram-negative bacilli.Sixty-five patients (14.4%) initially received combined antibiotic therapy,of which 30.8% were deemed as overuse.Among 308 patients who initially received broad-spectrum antibiotic therapy,268 patients (87.0%) clinically improved in five days,while de-escalation was only conducted in 72 cases (26.9%).On average,patients were treated with (2.29±1.30) antibiotics for a duration of (10.6±6.5) days,and 42.4% received combined antibiotic therapy during hospitalization.Conclusions The major microbiological pathogens in cIAI patients in our hospital were Enterobacteriaceae.However,there are phenomena such as excessive usage with broad-spectrum antibiotics,insufficient awareness of de-escalation,and long course of anti-infective therapy,which needs to be further improved.
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Zoonoses
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Emergency Medicine
Ano de publicação:
2019
Tipo de documento:
Artigo