Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume, and appropriate cut off values forprediction of early-stage diabeticnephropathy / 中华内分泌外科杂志

ABSTRACT

Objective To investigate and compare predictive diagnostic value of neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio and mean platelet volume,for early-stage diabetic nephropathy (EDN).Methods 245 patients with T2DM were divided into patients with EDN(EDN group,n=120) and patients without DN (T2DM group,n=125).116 healthy people were also enrolled in our study.Their clinical and biochemical data were collected.Results NLR (2.14±0.73 vs 1.78±0.58 vs 1.46±0.48,P＜0.05),PLR (116.11±36.43 vs 100.65±27.83 vs 90.24±26.17,P＜0.05) and MPV (11.29± 1.16 vs 10.37 ± 1.01 vs 9.78 ± 1.28,P＜0.05) were significantly higher in EDN group and T2DM group than those of the control group.NLR,PLR and MPV were significantly higher in EDN group than those of T2DM group.Logistic regression analysis showed that after correction of diabetes duration,blood pressure,lipid,and so on,NLR(OR=3.77,95％ CI 2.12-6.08,P＜0.01),PLR(OR=1.81,95％ CI 1.02-2.89,P=0.04) and MPV (OR=2.08,95％ CI 1.22-5.04,P=0.01) were all positively correlated with EDN.According to the analysis of ROC curves,the value of NLR for predicting EDN was higher than PLR and MPV.The cut off value of NLR for predicting EDN was set at 1.82,with the sensitivity of 79.20％ and the specificity of 68.60％.Conclusion NLR has the greatest diagnostic value for EDN,patients whose NLR is over 1.82 need further test in order to diagnose and therapy DN earlier.