A systematic review of Yang Yin Sheng Ji pulvis (membranae) for the treatment of recurrent oral ulcer / 实用口腔医学杂志

ABSTRACT

Objective: To systematically evaluate the efficacy and safety of Yang Yin Sheng Ji pulvis (membranae) in the treatment of recurrent oral ulcers (ROU) . Methods: All clinical studies of Yang Yin Sheng Ji pulvis (membranae) for the treatment of ROU were searched from Cochrane Library (Issue 5, 2017), Pub Med, PMC, Medline, EMBASE, CNKI, CBM, VIP and WANFANG DATA.The quality of the included studies was evaluated referring to the Cochrane Reviewer's Handbook 5. 1. 0, Meta-analysis of the total effective rate was performed using Rev Man 5. 3. 5 software, ITC software was used to compare the efficacy of Yang Yin Sheng Ji pulvis and Yang Yin Sheng Ji membranae in Meta. Results: 11 studies including 1837 patients were included. The results of Meta-analysis showed that Yang Yin Sheng Ji pulvis (membranae) for the treatment of ROU is more effective than the roultine treatment (OR = 5. 22, 95％ CI3. 93 ～ 6. 93, P ＜ 0. 000 01), subgroup analysis showed that Yang Yin Sheng Ji pulvis and Yang Yin Sheng Ji membrane are superior to the routine treatment (OR = 5. 08, 95％ CI 3. 63 ～ 7. 10, P ＜ 0. 000 01 and OR = 6. 67 95％ CI 3. 82 ～ 11. 66, P ＜ 0. 000 01), respectively. Indirect comparison results showed that the total efficiency of Yang Yin Sheng Ji membrane is higher than that of Yang Yin Sheng Ji Pulvis (P = 0. 009) . No adverse reaction of Yang Yin Sheng Ji pulvis (membrane) was reported. Conclusion: Yang Yin Sheng Ji pulvis (membranae) is more effective in the treatment of ROU than the routine treatment.