Application of coagulation biomarkers in the diagnosis of thrombotic diseases in critically ill children / 中国小儿急救医学

ABSTRACT

Thrombotic diseases in children are much rare compared with adults,and the incidences are increasing in PICU during recent years.The characters of clinical presentations and the results of laboratory tests are different among various kinds of thrombotic diseases in children with venous thromboembolism,arterial thrombosis and thrombotic microangiopathy.The pathophysiological mechanism of thrombotic diseases comprise of coagulation activation and fibrinolysis suppression.Biomarkers of coagulation can reflect the early situation of coagulation and fibrinolysis.Fully and reasonably understanding the changes of various coagulation biomarkers in children is helpful for the early prediction and diagnosis of thrombotic disease.