Neuropharmacological evaluation of methanolic extract of Costus speciosus Linn. rhizome in Swiss albino mice
Asian Pacific Journal of Tropical Biomedicine
; (12): 217-221, 2019.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-744069
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To evaluate the neuropharmacological properties of Costus speciosus (C. speciosus) rhizome using different experimental mouse models.Methods:
The anxiolytic effect was investigated by hole-board test, elevated plus maze and light/dark test, while central nervous system (CNS) depressant effect was evaluated by thiopental sodium-induced sleep test. Finally, antidepressant effect was evaluated by forced swimming test and tail suspension test.Results:
In both elevated plus maze and hole board test, 400 mg/kg C. speciosus showed more significant CNS depressant effect than 1 mg/kg diazepam. Both 200 mg/kg and 400 mg/kg C. speciosus extract produced a significant dose-dependent decrease in onset of sleep. In forced swimming test, C. speciosus rhizome showed a decrease in duration of immobility in a dose-dependent manner. Imipramine (10 mg/kg) and C. speciosus extract at 400 mg/kg dose exhibited a significant reduction in duration of immobility in tail suspension test which provided additional evidence of antidepressant effect of C. speciosus rhizome.Conclusions:
Our study indicates that C. speciosus rhizome possesses CNS depressant, anxiolytic and antidepressant-like activities. Further studies are warranted determine the exact phytoconstituents and mechanism of action responsible for the neuropharmacological effect.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Asian Pacific Journal of Tropical Biomedicine
Ano de publicação:
2019
Tipo de documento:
Artigo