Association between Peri-Implantitis and Gene Polymorphism of Interleukin-1 / 中国医科大学学报
Journal of China Medical University
; (12): 250-254, 2019.
Article
em Zh
| WPRIM
| ID: wpr-744835
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the relationship between gene polymorphism of interleukin (IL) -1 and peri-implantitis. Methods A case-control experimental design was used in this study. Moreover, using a bioinformatics analysis, we selected three tagged single nucleotide polymorphisms (SNP) suitable for the Chinese population. Patients with peri-implantitis (n = 116) and 87 patients without peri-implantitis were included. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to tag SNP of IL-1α, IL-1β, and IL-1γn. Results The rs2856838 locus of the AA genotype of IL-1α was associated with a higher risk of implant periodontitis than the GG genotype. There was no statistical difference between the two groups with regard to the other SNP. Conclusion The AA genotype of rs2856838 is associated with periprosthetic inflammation.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of China Medical University
Ano de publicação:
2019
Tipo de documento:
Article