Advances in the extracellular domain of p75 neurotrophin receptor in the prevention and therapy of Alzheimer's disease / 中华神经科杂志
Chinese Journal of Neurology
; (12): 226-231, 2019.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-745918
Biblioteca responsável:
WPRO
ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairments with progressive loss of memory and behavioral disorder.Up to now,there is no effective therapy or drug to cure AD.Recent studies have shown p75 neurotrophin receptor (p75NTR) plays a critical role in the pathogenesis of AD,while the extracellular domain of p75 neurotrophin receptor (p75ECD) has neuroprotective effect and can attenuate the development and progression of AD.Therefore,p75ECD is a research-hotspot for prevention and treatment of AD.Here,recent studies are reviewed to learn about the advances of p75ECD in the prevention and therapy of AD and provide references for getting novel methods and drugs to treat AD.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
Problema de saúde:
Objetivo 10: Doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Neurology
Ano de publicação:
2019
Tipo de documento:
Artigo