Meta-analysis of association between MMP-1-1607 polymorphism and head and neck cancer risk in asia population / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To analyze and explore the association between the 1607(1G/2G) single nucleotide polymorphism (SNP) in promoter of matrix metalloproteinase-1 (MMP-1) gene and susceptibility of head and neck cancer (HNC) by Meta-analysis.@*METHOD@#By the end of January 2014, the published literatures were collected for the case-control studies evaluating the relationship between HNC and -1607 SNP of MMP-1 gene from English and Chinese literature databases according to the inclusion and exclusion criteria. Then the meta-analysis, the heterogeneity, bias and sensitivity of the results of the eligible literatures were conducted by Stata 10. 0.@*RESULT@#A total of 9 studies including 2049 patients with HNC and 2158 controls were extracted for systematic review on the association of MMP-1 (-1607) 1G/2G SNP with the risk of HNC. Meta-analysis which based on random effects model showed that MMP-1 (-1607) 1G/2G SNP can significantly increase the risk of HNC[1G2G + 2G2G vs. 1G1G OR = 1.45, 95% CI 1.25-1.68, P < 0.01; 2G2G vs. 1G1G + 1G2GOR = 1.77, 95% CI 1.37-2.30, P < 0.01; 2G vs. 1G OR = 1.52, 95% CI 1.26-1.85, P < 0.01; 2G2G vs. 1G1G OR = 2.06, 95% CI 1.41-3.01, P < 0.01).@*CONCLUSION@#MMP-1 (-1607) 1G/2G SNP has close relationship with HNC susceptibility, people who with 2G2G genotype carriers are susceptible to HNC.