Expressions of cyclin D1 and p16 in hypopharyngeal squamous cell carcinoma and their clinical significance / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 406-409, 2007.
Article
em Zh
| WPRIM
| ID: wpr-748408
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study the expressions of Cyclin D1 and p16 proteins in hypopharyngeal squamous cell carcinoma and their clinical significance.@*METHOD@#Immunohistochemical technology (P-V) was applied to detect the expression of Cyclin D1 and p16 in 36 cases of hypopharyngeal squamous cell carcinoma and 10 cases of normal epithelium.@*RESULT@#(1) The expression of cyclin D1 in the tumorous cell was significantly higher than that in normal epithelium (P 0.05); (3) There was correlation between the expression of Cyclin D1 and the expression of p16 (r(s) = -0.420, P < 0.05).@*CONCLUSION@#The over-expression of Cyclin D1 and the under-expression of p16 may play a significant role in the occurrence incidence and development of hypopharyngeal squamous cell carcinoma, and may be important indicators for cervical lymph node metastases.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Prognóstico
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Carcinoma de Células Escamosas
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Neoplasias Hipofaríngeas
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Estudos de Casos e Controles
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Ciclina D1
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Inibidor p16 de Quinase Dependente de Ciclina
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Metástase Linfática
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Metabolismo
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2007
Tipo de documento:
Article