Clinical features and treatment of nasal mucosa-associated lymphoid tissue lymphoma / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To explore the clinical features and treatment of nasal mucosa-associated lymphoid tissue lymphoma (MALTL).@*METHOD@#The data of 11 patients with nasal MALTL were analyzed retrospectively during 9 years, including their clinical features and effectiveness of treatment. Nine cases were male and 2 female, their age arranged from 18 to 49 years with an average age of 39 years. All cases underwent endoscopic sinus surgery, and were diagnosed by HE staining and immunohistochemistry. After operation, 7 cases were cured with immunotherapy and antibiotic therapy. Other 4 patients were treated by chemotherapy, radiotherapy, immunotherapy and antibiotic therapy.@*RESULT@#During follow up 6-36 months, 4 patients died and other 7 patients achieved complete remission.@*CONCLUSION@#Clinical manifestations of nasal MALTL are not typical,which is apt to be misdiagnosed and mistreated. The suspected lesion tissues under endoscopy should be completely resected and submitted to pathology investigation. Nasal MALTL is a subtype of non-Hodgkin lymphoma which is characterized by occult onset, long course, slow progression and low cure rates in the advanced stage.