Study on relationship between intratumoral lymphangiogenesis of laryngeal squamous cell carcinoma and lymphatic metastasis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 385-388, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-749064
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To elucidate the relationship between the intratumoral lymphangiogenesis and lymphatic metastasis, and provide some theoretic evidence for the judgement of lymph node metastasis and prognosis of laryngeal squamous cell carcinoma (LSCC), also for the treatment.@*METHOD@#Immunohistochemical analysis was performed to 50 specimens of LSCC with lymphatic endothelial marker (Lymphatic vessel endothelial hyaluronan receptor-1 LYVE-1), the vascular endothelial marker CD34 and the pKi67 proliferation marker to record lymphatic vessel density (LVD). Quantitation of lymphangiogenesis growth factor VEGF-C by RT- PCR was performed to 30 specimens of LSCC. Finally the correlation between LVD and tumor TNM grade, VEGF-C mRNA, grade of diffraction was analyzed with statistics methods.@*RESULT@#Newly proliferating lymphatic vessel were observed in all LSCC. The median copy number of VEGF-c mRNA was 4-5-fold higher in LSCC than in adjacent normal tissue. There was correlation between tumor VEGF-C mRNA copy number and intratumoral LVD (n =30, P 0.05) but N stage (n = 50, P <0.05).@*CONCLUSION@#Newly proliferating lymphatic vessels existed in LSCC. There was correlation between high levels of LVD in LSCC than in normal tissue. And the high level of VEGF-C may accelerate the lymphatic metastasis by promoting the proliferation of intratumoral lymphatic.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
/
Vasos Linfáticos
/
Fator C de Crescimento do Endotélio Vascular
/
Linfangiogênese
/
Metástase Linfática
/
Metabolismo
/
Estadiamento de Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2008
Tipo de documento:
Artigo