Differences in airway inflammation according to atopic status in patients with chronic rhinitis
Asia Pacific Allergy
; (4): 248-255, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-749919
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Chronic rhinitis is a heterogeneous group of diseases that cause nasal inflammation. And the nose may be a window into the lung in the concept of "one airway one disease."OBJECTIVE:
This study was conducted to evaluate differences between the different forms of chronic rhinitis in terms of lower airway inflammation.METHODS:
Patients that attended the allergy clinic and presented with moderate/severe persistent rhinitis symptoms for more than 1 year were enrolled. The patients with chronic rhinitis were classified into two groups (house dust mites [HDM]-sensitive allergic rhinitis [AR] or non-allergic rhinitis [NAR]) according to the presence of atopy, and additionally according to nasal polyposis and airway hyperresponsiveness, respectively. Medical records were reviewed and the mRNA expression levels of IL-5, IFN-γ, TGF-β1, IL-17A, and IL-25 were evaluated in induced sputum samples in each group.RESULTS:
Induced sputum samples of 53 patients were evaluated. Patients with NAR were significantly older than patients with HDM-sensitive AR (p < 0.05). Nasal polyposis was more prevalent in NAR patients than in HDM-sensitive AR patients (10.2% vs. 62.5%, p < 0.001). The expression levels of IL-17A mRNA were higher in NAR patients, regardless of the presence of airway hyperresponsiveness (p = 0.005).CONCLUSION:
These results suggest that patients with different forms of chronic rhinitis could have different inflammatory environments in their lower airway and NAR patients might have bronchial inflammation related to the elevated levels of IL-17A compared to HDM-sensitive AR patients.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Escarro
/
RNA Mensageiro
/
Rinite
/
Pólipos Nasais
/
Nariz
/
Prontuários Médicos
/
Interleucina-5
/
Interleucina-17
/
Poeira
Limite:
Humanos
Idioma:
Inglês
Revista:
Asia Pacific Allergy
Ano de publicação:
2012
Tipo de documento:
Artigo