Association between genetic polymorphisms of TERT with susceptibility of age-related macular degeneration / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM: To investigate the relationship between single nucleotide polymorphism(SNP)in the TERT gene and risk of age-related macular degeneration(ARMD).<p>METHODS: Seven reported SNPs in TERT were selected and genotyped using SEQUENOM MassArray technology in 191 ARMD patients and 197 healthy normal controls. The correlations of the alleles, genotypes and the susceptibility of ARMD were evaluated by Logistic regression analysis.<p>RESULTS: The frequencies of SNP rs10069690 CC, CT, TT genotypes in ARMD patients were 64.4%, 31.4%, 4.2% compared with 74.6%, 22.8%, 2.5% in normal controls, respectively. Genetic model analysis revealed that SNP rs10069690 CT+TT genotypes were significantly associated with an increased risk of ARMD patients(<i>OR</i>=1.63, 95% <i>CI</i>=1.05-2.53).<p>CONCLUSION: SNP rs10069690 in the TERT gene is associated with the risk of ARMD.