Genome-scale analysis of demographic history and adaptive selection
Protein & Cell
; (12): 99-112, 2014.
Article
em En
| WPRIM
| ID: wpr-757525
Biblioteca responsável:
WPRO
ABSTRACT
One of the main topics in population genetics is identification of adaptive selection among populations. For this purpose, population history should be correctly inferred to evaluate the effect of random drift and exclude it in selection identification. With the rapid progress in genomics in the past decade, vast genome-scale variations are available for population genetic analysis, which however requires more sophisticated models to infer species' demographic history and robust methods to detect local adaptation. Here we aim to review what have been achieved in the fields of demographic modeling and selection detection. We summarize their rationales, implementations, and some classical applications. We also propose that some widely-used methods can be improved in both theoretical and practical aspects in near future.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
/
Seleção Genética
/
Adaptação Fisiológica
/
Demografia
/
Genoma
/
Evolução Molecular
/
Genética
/
Genética Populacional
/
Modelos Genéticos
Tipo de estudo:
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
Idioma:
En
Revista:
Protein & Cell
Ano de publicação:
2014
Tipo de documento:
Article