The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age
Asia Pacific Allergy
; (4): e33-2019.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-762876
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship.OBJECTIVE:
We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period.METHODS:
We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2–4 years.RESULTS:
The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2–4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184–2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135–1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood OR, 1.242; 95% CI, 0.353–4.368; for 1-year peripheral-blood OR, 1.451; 95% CI, 0.428–4.919).CONCLUSION:
There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Broncopatias
/
Estudos de Coortes
/
Seguimentos
/
Telômero
/
Estresse Oxidativo
/
Parto
/
Hipersensibilidade
/
Leucócitos
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança, pré-escolar
/
Humanos
Idioma:
Inglês
Revista:
Asia Pacific Allergy
Ano de publicação:
2019
Tipo de documento:
Artigo