Determining the risk factors associated with the development of Clostridium difficile infection in patients with hematological diseases
Blood Research
; : 120-124, 2019.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-763061
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Clostridium difficile infection (CDI) is a nosocomial condition prevalent in patients with hematological disorders. We aimed to identify the risk factors associated with the development of CDI and assess the mortality rate at 15 and 30 days among hematologic patients admitted to a tertiary care center.METHODS:
We conducted a retrospective case-control study from January 2010 to December 2015. Forty-two patients with hematologic malignancy and CDI, and 84 with hematologic disease and without history of CDI were included in the case and control groups, respectively.RESULTS:
Univariate analysis revealed that episodes of febrile eutropenia [odds ratio (OR), 5.5; 95% confidence interval (CI), 2.3–12.9; P1 hospitalization (OR, 5.6; 95% CI, 2.5–12.6; P1 hospitalization (OR, 4.3; 95% CI, 1.7–11.0; P=0.002) were independent risk factors. Three (7.1%) and 6 (14.2%) case patients died at 15 and 30 days, respectively.CONCLUSION:
The risk factors for developing CDI were exposure to therapeutic antibiotics and previous hospitalization. Hematological patients who developed CDI had higher early mortality rates, suggesting that new approaches for prevention and treatment are needed.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estudos de Casos e Controles
/
Análise Multivariada
/
Estudos Retrospectivos
/
Fatores de Risco
/
Mortalidade
/
Clostridioides difficile
/
Clostridium
/
Neoplasias Hematológicas
/
Centros de Atenção Terciária
/
Doenças Hematológicas
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Blood Research
Ano de publicação:
2019
Tipo de documento:
Artigo