Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala
Experimental Neurobiology
; : 320-328, 2019.
Article
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| ID: wpr-763772
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WPRO
ABSTRACT
The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors: formation and extinction of fear memory and appetitive instrumental learning. However, the cholinergic mechanism at the circuit level has not been defined yet. We demonstrated that cholinergic-induced di-synaptic inhibition of BLA pyramidal neurons exhibits a retrograde form of short-term synaptic inhibition, depolarization-induced suppression of inhibition (DSI). Activation of nicotinic receptors was sufficient to evoke action potentials in cholecystokinin (CCK)-positive inhibitory neurons, which strongly inhibit pyramidal neurons through their perisomatic synapses. Our cell type-specific monosynaptic retrograde tracing also revealed that CCK neurons are innervated by basal forebrain cholinergic neurons. Therefore, our data indicated that CCK inhibitory neurons mediate the cholinergic-induced di-synaptic inhibition of BLA pyramidal neurons.
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Assunto principal:
Sinapses
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Potenciais de Ação
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Colecistocinina
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Acetilcolina
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Iontoforese
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Receptores Nicotínicos
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Células Piramidais
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Condicionamento Operante
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Neurônios Colinérgicos
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Complexo Nuclear Basolateral da Amígdala
Idioma:
En
Revista:
Experimental Neurobiology
Ano de publicação:
2019
Tipo de documento:
Article