Role of proteases, cytokines, and growth factors in bone invasion by oral squamous cell carcinoma
International Journal of Oral Biology
; : 37-42, 2019.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-764040
Biblioteca responsável:
WPRO
ABSTRACT
Oral squamous cell carcinoma (OSCC) is the most common oral malignancy and an increasing global public health problem. OSCC frequently invades the jaw bone. OSCC-induced bone invasion has a significant impact on tumor stage, treatment selection, patient outcome, and quality of life. A number of studies have shown that osteoclast-mediated bone resorption is a major step in the progression of bone invasion by OSCC; however, the molecular mechanisms involved in OSCC bone invasion are not yet clear. In this review, we present the clinical types of OSCC bone invasion and summarize the role of key molecules, including proteases, cytokines, and growth factors, in the sequential process of bone invasion. A better understanding of bone invasion will facilitate the discovery of molecular targets for early detection and treatment of OSCC bone invasion.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peptídeo Hidrolases
/
Qualidade de Vida
/
Reabsorção Óssea
/
Carcinoma de Células Escamosas
/
Saúde Pública
/
Citocinas
/
Seleção de Pacientes
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Células Epiteliais
/
Arcada Osseodentária
Tipo de estudo:
Estudo de rastreamento
Aspecto:
Determinantes sociais da saúde
/
Preferência do paciente
Idioma:
Inglês
Revista:
International Journal of Oral Biology
Ano de publicação:
2019
Tipo de documento:
Artigo