The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease
Journal of Clinical Neurology
; : 517-526, 2019.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-764364
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
Associations between alterations in body mass index (BMI) and cognitive function have been reported in Parkinson's disease (PD). We investigated whether the BMI at a PD diagnosis is associated with cognitive decline and the future development of dementia.METHODS:
We recruited 70 patients with de novo PD who underwent neuropsychological testing every 3 years and were followed up for more than 6 years. We classified patients into the following three groups based on their BMI at the diagnosis under-/normal weight (n=21), overweight (n=22), and obese (n=27). We evaluated differences in the rate of cognitive decline over time among the groups using linear mixed models and the conversion rate to dementia using survival analysis.RESULTS:
The obese patients with PD showed a slower deterioration of global cognitive function as well as language and memory functions than did the under-/normal-weight group during the 6-year follow-up. The three BMI groups showed different rates of conversion to dementia (log-rank test p=0.026). The combined overweight and obese group showed a lower risk of developing dementia compared with the under-/normal-weight group (hazard ratio= 0.36, 95% CI=0.12–0.82, p=0.046).CONCLUSIONS:
We have demonstrated that a higher-than-normal BMI at the time of a PD diagnosis has a protective effect against the deterioration of cognitive function and the conversion to dementia.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Doença de Alzheimer e outras Demências
/
Doenças do Sistema Endócrino
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Saúde Mental e Transtornos do Comportamento
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Obesidade
/
Doença de Parkinson
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Índice de Massa Corporal
/
Seguimentos
/
Cognição
/
Demência
/
Diagnóstico
/
Sobrepeso
/
Memória
/
Testes Neuropsicológicos
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Clinical Neurology
Ano de publicação:
2019
Tipo de documento:
Artigo