The Protective Effect of Maternal Folic Acid Supplementation on Childhood Cancer: A Systematic Review and Meta-analysis of Case-control Studies / 예방의학회지
Korean Journal of Preventive Medicine
; : 205-213, 2019.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-766147
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES:
Maternal folic acid supplementation is considered mandatory in almost every country in the world to prevent congenital malformations. However, little is known about the association of maternal folic acid intake with the occurrence of childhood cancer. Hence, this study aimed to determine the effects of maternal folic acid consumption on the risk of childhood cancer.METHODS:
A total of 158 related articles were obtained from PubMed, Google Scholar, Scopus, and ProQuest using standardized keywords, of which 17 were included in the final review.RESULTS:
Eleven of the 17 articles showed a significant protective association between maternal folic acid supplementation and childhood cancer. Using a random-effects model, pooled odds ratios (ORs) showed a protective association between maternal folic acid supplementation and childhood acute lymphoblastic leukaemia (OR, 0.75; 95% confidence interval [CI], 0.66 to 0.86). However, there was no significant association between maternal folic acid supplementation and acute myeloid leukaemia (OR, 0.70; 95% CI, 0.46 to 1.06) or childhood brain tumours (OR, 1.02; 95% CI, 0.88 to 1.19).CONCLUSIONS:
Maternal folic acid supplementation was found to have a protective effect against childhood acute lymphoblastic leukaemia. Thus, healthcare professionals are recommended to provide regular health education and health promotion to the community on the benefits of folic acid supplementation during pregnancy.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3C Aumentar o financiamento da saúde e o recrutamento, desenvolvimento, formação e retenção da força de trabalho da saúde
/
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Autoridade e Responsabilidade dos Profissionais de Saúde
/
Objetivo 9: Redução de doenças não transmissíveis
/
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Encéfalo
/
Estudos de Casos e Controles
/
Razão de Chances
/
Educação em Saúde
/
Atenção à Saúde
/
Ácido Fólico
/
Promoção da Saúde
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
/
Revisão sistemática
Aspecto:
Determinantes sociais da saúde
Limite:
Gravidez
Idioma:
Inglês
Revista:
Korean Journal of Preventive Medicine
Ano de publicação:
2019
Tipo de documento:
Artigo