A new isoflavone derivative from Rosa Damascena and its antibacterial activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 332-335, 2018.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-771733
Biblioteca responsável:
WPRO
ABSTRACT
A new isoflavone derivative was isolated from Rosa damascena by using various chromatographic techniques including silica gel, Sephadex LH-20, and preparative RP-HPLC separation. Its structure was identified as 4'-hydroxy-7-(3-hydroxypropanoyl)-6-methoxy-isoflavone using combined examinations of their UV, IR, MS, and NMR spectroscopic data. Biological activity test showed that this compound showed prominent antibacterial activity with MIC₉₀ value of (46±4) mg·L⁻¹ for methicillin resistant Staphylococcus aureus(MRSA) strain. This value is close to that of levofloxacin [with MIC₉₀ value (53±5) mg·L⁻¹].
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Testes de Sensibilidade Microbiana
/
Química
/
Rosa
/
Staphylococcus aureus Resistente à Meticilina
/
Compostos Fitoquímicos
/
Isoflavonas
/
Antibacterianos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2018
Tipo de documento:
Artigo