Effects of Lidocaine and Propofol on Production of Interleukin (IL)-2, IL-4, and Nitric Oxide in Mice / 대한마취과학회지
Korean Journal of Anesthesiology
; : 671-678, 2005.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-77298
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
The possibility that anesthesia may alter the course of an infection has been under consideration for more a century. Alterations have been found in every component of the immune response during anesthesia and surgery. In this work, we have investigated the effect of lidocaine and propofol on interleukin-2 (IL-2), interleukin-4 (IL-4), and nitric oxide (NO) production in mice.METHODS:
The culture supernatants of splenocytes exposed with anesthetics and lipopolysaccharide (LPS), or sera from mice injected with these agents were harvested to assay IL-2, IL-4, and NO.RESULTS:
We detected that IL-2 productions of splenocytes culture supernatants and mice sera after exposure with lidocaine or propofol were decreased while IL-4 productions were increased. In addition, NO of mice sera was increased after lidocaine or propofol exposures.CONCLUSIONS:
These findings suggest that lidocaine and propofol interfere with IL-2, IL-4, and NO production. This may explain the clinically well-recognized disturbance of human immunity after surgery and anesthesia.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Propofol
/
Interleucinas
/
Interleucina-4
/
Interleucina-2
/
Anestesia
/
Anestésicos
/
Lidocaína
/
Óxido Nítrico
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2005
Tipo de documento:
Artigo