Study on sesquiterpenes from agarwood originating from Gyrinops salicifolia / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2274-2277, 2019.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-773097
Biblioteca responsável:
WPRO
ABSTRACT
Two sesquiterpenes were isolated from the agarwood originating from Gyrinops salicifolia with various chromatographic techniques, and their structures were determined as 12-hydroxy-dihydrocyperolone(1) and(rel)-4β,5β,7β-eremophil-9-en-12,8α-olide(2), through a combined analysis of physicochemical properties and spectroscopic evidence. Compound 1 was a new compound. Compound 2 showed cytotoxicities against K562 and BEL-7401 cell lines, with IC_(50) values of(17.85±0.04) and(21.82±0.07) mg·L~(-1), respectively [taxol as positive control, with IC_(50) values of(1.97±0.11) and(6.31±0.08) mg·L~(-1)].
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Sesquiterpenos
/
Madeira
/
Estrutura Molecular
/
Química
/
Thymelaeaceae
/
Linhagem Celular Tumoral
/
Compostos Fitoquímicos
/
Antineoplásicos Fitogênicos
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2019
Tipo de documento:
Artigo