Efficacy and Safety of Apatinib in Treating Advanced Colorectal Cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 170-174, 2019.
Article
em Zh
| WPRIM
| ID: wpr-776054
Biblioteca responsável:
WPRO
ABSTRACT
Objective To assess the efficacy and safety of apatinib in the treatment of advanced colorectal cancer(CRC). Methods The clinical data of 16 CRC patients treated with apatinib after failure of prior lines of treatment were retrospectively analyzed in terms of objective response rate,disease control rate,progression-free survival,overall survival,adverse events,and prognostic factors. Results The efficacy was evaluable in 14 patients,among whom the objective response rate was 7.1% and the disease control rate was 50%.The median progression-free survival was 3 months(95%CI=1.57-4.42),and the median overall survival was 6.5 months(95%CI=4.10-8.89).The safety was evaluable in 16 patients,among whom the most common grade 3 adverse events were hypertensinon(37.5%)and proteinuria(25%).No grade 4 adverse event was observed.Multivariate analysis did not show any factor directly related to survival.Conclusion Apatinib may be effective in treating advanced CRC,with tolerable side effects.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Piridinas
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Neoplasias Colorretais
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Análise de Sobrevida
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Estudos Retrospectivos
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Usos Terapêuticos
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Tratamento Farmacológico
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Antineoplásicos
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2019
Tipo de documento:
Article