A case with a novel weak D type / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 731-733, 2019.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-776818
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To report on a novel weak D type identified in a Chinese individual.@*METHODS@#Peripheral blood sample was collected for a voluntary blood donor with weakened expression of D antigen. Routine serological testing was carried out to determine the D, C, c, E and e antigens of the Rh blood group. A D-screening kit was used to analyze the RhD epitopes. The 10 exons and flanking intronic regions of the RHD gene were sequenced. The zygosity of RHD was determined with a sequence-specific primer PCR method.@*RESULTS@#A novel RHD allele, RHD (1022T>A), was found in the subject with a weak D phenotype. Serological testing of the RhD epitopes has coined with the weak D phenotype.@*CONCLUSION@#A novel weak D allele has been identified in Chinese population.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sistema do Grupo Sanguíneo Rh-Hr
/
Íntrons
/
China
/
Éxons
/
Povo Asiático
/
Alelos
/
Genética
/
Genótipo
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2019
Tipo de documento:
Artigo