Spinal Mechanisms of Itch Transmission / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 156-164, 2018.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-777082
Biblioteca responsável:
WPRO
ABSTRACT
Peripheral itch stimuli are transmitted by sensory neurons to the spinal cord dorsal horn, which then transmits the information to the brain. The molecular and cellular mechanisms within the dorsal horn for itch transmission have only been investigated and identified during the past ten years. This review covers the progress that has been made in identifying the peptide families in sensory neurons and the receptor families in dorsal horn neurons as putative itch transmitters, with a focus on gastrin-releasing peptide (GRP)-GRP receptor signaling. Also discussed are the signaling mechanisms, including opioids, by which various types of itch are transmitted and modulated, as well as the many conflicting results arising from recent studies.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Fisiologia
/
Prurido
/
Células Receptoras Sensoriais
/
Medula Espinal
/
Potenciais de Ação
/
Transmissão Sináptica
/
Analgésicos Opioides
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Neuroscience Bulletin
Ano de publicação:
2018
Tipo de documento:
Artigo