Advances in research and application of liver organoids / 临床肝胆病杂志
Journal of Clinical Hepatology
; (12): 2342-2345, 2019.
Article
em Zh
| WPRIM
| ID: wpr-778748
Biblioteca responsável:
WPRO
ABSTRACT
Liver diseases significantly affect human health. Classic research models cannot maintain hepatocyte polarity for a long time and have a different genetic background from normal human hepatocytes, which limits the research on the physiological functions of hepatocytes and the mechanisms of related diseases. The latest liver organoid technology can obtain liver organoids with partial liver structure by reprogrammed induced pluripotent stem cells or in vitro culture of liver biopsy tissue and maintain long-term proliferation and genetic stability, and therefore, it is expected to become a powerful tool for disease modelling, drug screening, and cell therapy. This article mainly reviews the research and application of liver organoids in recent years.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Clinical Hepatology
Ano de publicação:
2019
Tipo de documento:
Article