Association between fasting glucose and branchial-ankle pulse wave velocity among hypertensive population in rural areas of Eastern China / 中华疾病控制杂志

ABSTRACT

Objective To explore the relationship between fasting blood glucose and branchial-ankle pulse wave velocity (baPWV) levels among hypertensive population in rural areas of Eastern China. Methods A cross-sectional analysis were conducted among hypertensive population in Lianyungang and Anqing city from July to September 2013. Multivariable linear regression models were used to analyze the association of serum glucose and baPWV. Results A total of 3 894 hypertensive participants were included in the present study. The prevalence of normal fasting glucose (NFG), impaired fasting glucose (IFG) and diagnosed diabetes (DM) were 44.5%, 43.0%, and 12.5%, respectively. Each 1-mmol/L increase in fasting blood glucose levels was significantly associated with a 26.2 cm/s increase in baPWV levels (95% CI 19.6-32.8, P<0.001). Consistently, significantly higher baPWV levels were observed in participants with IFG (β=50.4 cm/s, 95% CI 28.4-72.3, P<0.001) and DM (β=113.4 cm/s, 95% CI 80.2-146.5, P<0.001) when compared to those with NFG. Furthermore, a stronger positive association between fasting blood glucose and baPWV was observed in participants with systolic blood pressure (SBP) ≥140 mmHg (β=34.3 cm/s, 95% CI 24.5-44.2, P<0.001; vs.<140 mmHg; β=18.1 cm/s, 95% CI 9.1-27.2, P<0.001; Pinteraction=0.027). Conclusion There was a positive association between fasting blood glucose and baPWV levels among hypertensive population in rural areas of Eastern China.