BONE REGENERATION WITH INJECTABLE MPEG-PCL DIBLOCK COPOLYMER AND BONE MARROW MESENCHYMAL STEM CELL
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
; : 9-15, 2010.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-784955
Biblioteca responsável:
WPRO
ABSTRACT
injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model.MATERIALS AND METHODS:
New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis.RESULTS:
The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer.CONCLUSION:
It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoblastos
/
Osteogênese
/
Poliésteres
/
Polietilenoglicóis
/
Osso e Ossos
/
Medula Óssea
/
Regeneração Óssea
/
Transplantes
/
Hidrogéis
/
Células-Tronco Mesenquimais
Limite:
Animais
Idioma:
Coreano
Revista:
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Ano de publicação:
2010
Tipo de documento:
Artigo