Anti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)
Natural Product Sciences
; : 304-310, 2019.
Article
em En
| WPRIM
| ID: wpr-786430
Biblioteca responsável:
WPRO
ABSTRACT
The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in lipopolysaccharide-treated macrophages, RAW 264.7 cell. OE reduces inducible nitric oxide (NO) synthase-induced NO production, and interferes with mitogen-activated protein kinase activation pathways. In the present study, the pharmacological action of the water extract of OE was examined to establish anti-arthritic action, using a rat model of adjuvant-induced arthritis (AIA). The water extract of OE administered orally inhibited AIA-induced arthritis at (100 – 300) mg/kg/day. The paw edema was significantly decreased, in combination with reduced production of pro-inflammatory cytokines. The action mechanism includes an inhibition of MAPKs/nuclear transcription factor-κB activation. These new findings strongly suggest that OE possesses anti-arthritic action, and may be used as a therapeutic agent in inflammation-related disorders, particularly in arthritic condition.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Artrite
/
Artrite Reumatoide
/
Proteínas Quinases
/
Água
/
Citocinas
/
Modelos Animais
/
Oplopanax
/
Medicina Herbária
/
Edema
/
Macrófagos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Natural Product Sciences
Ano de publicação:
2019
Tipo de documento:
Article