6-Thioguanine-Induced Hepatic Sinusoidal Obstruction Syndrome in a Leukemic Child with TPMT Heterozygote / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
; : 109-113, 2012.
Article
em Ko
| WPRIM
| ID: wpr-788468
Biblioteca responsável:
WPRO
ABSTRACT
Hepatic sinusoidal obstruction syndrome (hSOS) can be developed as a common complication after hematopoietic stem cell transplantation (HSCT), and rarely after 6-thioguanine-based chemotherapy without HSCT. A four-year-old boy with heterozygotic polymorphism for thiopurine methyltransferase (TPMT) developed hSOS after he received chemotherapy with cytarabine, cyclophosphamide, intrathecal methotrexate and 6-thioguanine (6-TG) as reconsolidation chemotherapy of acute lymphoblastic leukemia (ALL). He was treated with defibrotide, N-acetylcysteine, urusodeoxycholic acid, glutathione, and supportive care. He recovered completely in nine days without long-term complication, and completed chemotherapy with 6-mercaptopurine without severe complication. We report a case of hSOS developed in an ALL patient with TPMT heterozygote after 6-TG based reconsolidation chemotherapy.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polidesoxirribonucleotídeos
/
Acetilcisteína
/
Tioguanina
/
Hepatopatia Veno-Oclusiva
/
Metotrexato
/
Transplante de Células-Tronco Hematopoéticas
/
Ciclofosfamida
/
Citarabina
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Glutationa
Limite:
Child
/
Humans
Idioma:
Ko
Revista:
Clinical Pediatric Hematology-Oncology
Ano de publicação:
2012
Tipo de documento:
Article