Human Induced Pluripotent Stem Cells: Clinical Significance and Applications in Neurologic Diseases
Journal of Korean Neurosurgical Society
; : 493-501, 2019.
Article
em En
| WPRIM
| ID: wpr-788813
Biblioteca responsável:
WPRO
ABSTRACT
The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson’s disease, Alzheimer’s disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Traumatismos da Medula Espinal
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Doadores de Tecidos
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Genoma
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Medicina Regenerativa
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Células-Tronco Pluripotentes Induzidas
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Medicina de Precisão
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Terapia Baseada em Transplante de Células e Tecidos
Tipo de estudo:
Guideline
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Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2019
Tipo de documento:
Article