Synthesis and antifungal activities of novel triazole derivatives containing sulfur atoms / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 334-337, 2016.
Article
em Zh
| WPRIM
| ID: wpr-790624
Biblioteca responsável:
WPRO
ABSTRACT
Objective To design and synthesis novel triazole antifungal derivatives with dithiocarbamates side chain and study the antifungal activities .Methods Nine title compounds were synthesized and characterized by 1 H NMR ,MS spectra . The in vitro antifungal activities of all the compounds were evaluated against eight human pathogenic fungi .Results The title compounds exhibited strong antifungal activities .Some compounds showed excellent activities against Candida albicans with the MIC80 values less than 0 .125 g/ml ,6d was 64 times higher than that of Itraconazole .Conclusion The introduction of the propyl ,sulphur and benzyl moiety to the side chain could affect the antifungal activities .
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1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Pharmaceutical Practice
Ano de publicação:
2016
Tipo de documento:
Article