A study on immunologic response at different periods with different hepatitis B vaccine in infants / 预防医学

ABSTRACT

Objective To know the immunologic response at different periods with different hepatitis B vaccine(HepB)in infants.Methods From July 1 to December 31 in 2009,the local infants born from hepatitis B virus(HBV)surface antigen (HBsAg)negative mother in Ninghai were selected and received a 0.5 ml of 5 -μg HepB made by recombinant deoxyribonucleic acid (DNA)techniques in saccharomyces cerevisiae yeast (HepB -SCY)and those in Yuyao were selected and received a 0.5 ml of 10 -μg HepB made by recombinant DNA techniques in hansenula polymorpha yeast (HepB -HPY)with a 0 -1 -6 month schedule.The specimens of blood were collected at 7 months,12 months and 18 months after vaccination for testing antibody.Results At 7 months,12 months and 18 months after vaccination,the geometric mean concentration (GMC)of Anti -HBs in HepB -SCY group were 714.79 ±3.50 mIU /mL,259.89 ± 3.87 mIU /mL and 78.38 ±4.04 mIU /mL,respectively.While in HepB -HPY group were 2 420.76 ±3.51 mIU /mL, 703.55 ±3.46 mIU /mL and 171.32 ±3.76 mIU /mL,respectively.There was statistical significant difference of GMC between HepB -SCY group and HepB -HPY group(P <0.01).The percent of antibody <100 mIU /mL in HepB -SCY group were 6.39%,23.33% and 55.42%,and in HepB -HPY group,were 2.17%,5.17% and 31.95%,respectively. The difference between HepB -SCY group and HepB -HPY group had significantly statistical significance (P <0.01 ). Conclusion The immunologic response at different periods of HepB -HPY was better than that of HepB -SCY.