Expression of TRAIL (Apo-2L)/TRAIL Receptor System Related to Apoptosis at the Human Extraembryonic Tissues and Gestational Trophoblastic Disease / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 2156-2161, 2003.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-79243
Biblioteca responsável:
WPRO
ABSTRACT
Human uterus has been known as a immune privileged site for the product of conception. At the feto-maternal interface, Fas system is a underlying main mechanism of maternal immune acceptance. To date, the TRAIL (TNF-related apoptosis-inducing ligand) system is known to be another pivotal mechanism. OBJECTIVE:
To clarify the protein expression of TRAIL ligand and receptors in the normal and pathologic (preeclampsia, hydatidiform mole) placenta, chorioamnion, decidua.METHODS:
we investigated the expression of TRAIL system in the above-mentioned tissues by using Western Hybridization.RESULTS:
All tissues expressed TRAIL ligand and only a DcR2 among TRAIL receptors (DR4, DR5, DcR1, DcR2).CONCLUSION:
we demonstrated the expression of TRAIL ligand and DcR2 protein at the feto-maternal interface of the normal and pathologic pregnancies. Further study regarding the expression of other receptors and quantitative analysis between normal and pathologic pregnancies should be followed.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Placenta
/
Útero
/
Apoptose
/
Decídua
/
Doença Trofoblástica Gestacional
/
Receptores do Ligante Indutor de Apoptose Relacionado a TNF
/
Fertilização
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2003
Tipo de documento:
Artigo