A study on the association between preeclampsia and the related screening markers during the first and second trimester / 预防医学

ABSTRACT

Objective To explore the association between preeclampsia and the level of related screening markers during the first and second trimester. Methods The concentration of PAPP - A,free β - hCG of the pregnant women in the first trimester(from 10th to 13 + 6 th weeks)were detected. The concentration of AFP,free β - hCG and uE3 were detected by the same method in the second trimester(from 14th to 19 + 6 th weeks). Protein in the urine and blood pressure of the pregnant women was closely monitored during pregnancy,and the late pregnancy outcomes were followed up. The difference of the concentration of PAPP - A,free β - hCG in the first trimester and free β - hCG,AFP,uE3 in the second trimester between women with pregnancy hypertension and those without were analyzed. Results A total of 7 476 women accepted prenatal screening. There were 668 women developed pregnancy hypertension and the incidence rate was 8. 70% . And 260 women developed preeclampsia and the incidence rate was 3. 4% . There were 50 cases of early - onset preeclampsia and 210 cases of late - onset preeclampsia. The concentration of PAPP - A and free β - hCG of preeclampsia women, especially the early - onset preeclampsia women,were lower than those of normal women in the first trimester. In the early pregnancy diagnosis,accuracy of the area of early - onset preeclampsia under the ROC curve was 0. 823. There was no difference of concentration of free β - hCG,AFP,uE3 in the second trimester between women with or without preeclampsia (P > 0. 05). Conclusion The level of PAPP - A has a certain value for diagnosis of early - onset preeclampsia. Serum screening markers in the second trimester showed little clinical value on preeclampsia.