Role of microRNAs in the development of gliocyma / 中国基层医药

ABSTRACT

Glioma is a common tumor of the nervous system.In some gliomas, some of the expressions of microRNA are up-regulated.Some of them are down regulated.Some microRNA expressions promote the development of gliomas, while some microRNA exert inhibitory effects.MicroRNA is a small species, which is quite conservative in the evolution of species.It degrades messenger RNA or impedes its translation by guiding the silencing complex with target gene messenger RNA base pairs.Therefore, by studying the expression of microRNA in glioma, we can not only provide evidence for early diagnosis of glioma, but also provide a new plan for clinical treatment of glioma.By reading the literature, the expression of microRNA in glioma, the target of action and its effect on the biological characteristics of glioma were reviewed.