Retrospectively analysis of characteristics and risk factors of immune treatment-related hepatic adverse events in malignant tumor / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 50-54, 2020.
Article
em Zh
| WPRIM
| ID: wpr-799034
Biblioteca responsável:
WPRO
ABSTRACT
Objective@#To explore the clinical features and risk factors of hepatic injury due to immune checkpoint inhibitors (CPI) therapy in malignant tumor.@*Methods@#Data of 112 patients (64 men and 48 women) who received CPI between January 2016 and March 2019 in Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen Hospital, and Huazhong University of Science and Techology Union Shenzhen Hospital were retrospectively collected. The median age of these patients was 60 years.@*Results@#Hepatic adverse events were observed in 30 patients out of 112 patients (26.8%). Among them, the incidence of grade 3-5 hepatic adverse events were 7.14% (8/112). The median time of hepatic adverse event occurrence was 3 weeks (2-30) after undergoing therapy. The results of univariate and multivariate analyses showed that liver cancer was attributed to the CPI induced hepatitis (P<0.05). Patients with severe hepatic injury got almost complete resolution after receiving methlprednisolone for 4 to 6 weeks.@*Conclusion@#Live cancer is the risk factor of CPI-related hepatic adverse events.
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Base de dados:
WPRIM
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2020
Tipo de documento:
Article