Clinical effect and mechanism of compound herba houttuyniae mixture for the childern with macrolide-resistant myeoplasma pneumoniae / 国际中医中药杂志

ABSTRACT

Objective@#To observe the clinical effect of the Compound herba houttuyniae mixture combined with azithromycin for the children with macrolide-resistant mycoplasma pneumoniae(MRMPP) and investigate the bi-directional control mechanism of inflammatory response.@*Methods@#A total of 60 patients with MRMPP were randomly divided into control group and observation group of 30 patients each by random number table. Patients in control group took azithromycin, while patients in observation group took azithromycin and compound herba houttuyniae mixture. Both groups were treated 21 days.@*Results@#The total effective rate of observation group was 86.67%, while the control group was 56.67%, and the difference was statistical significance (χ2=5.253, P=0.022). The duration of fever (1.2 ± 0.3 d vs. 3.7 ± 2.2 d, t=6.293), cough (7.5 ± 2.3 d vs. 14.9 ± 3.7 d, t=9.232) in the observation group were significantly better than those in the control group (P<0.01). The serum concentrations of IL-6 (14.69 ± 8.26 pg/ml vs. 8.41 ± 5.26 pg/ml, t=3.512), IL-10 (6.23 ± 1.79 pg/ml vs. 3.47 ± 2.18 pg/ml, t=5.359), IL-17 (5.61 ± 2.77 pg/m vs. 2.09 ± 1.53 pg/ml, t=6.093) in the observation group were significantly decreased than the control group (P<0.01). There were fewer cases of gastrointestinal adverse events in the treatment group than in the control group (3 vs. 11 cases; χ2=4.565, P<0.05) and the number of abnormal liver function (2 vs. 9 cases; χ2=4.007, P<0.05).@*Conclusions@#Compound herba houttuyniae mixture combined with azithromycin could improve the clinical symptoms and signs, and shorten the symptoms duration and reduce the side reaction.