Oxidative damage effects induced by CdTe quantum dots in mice / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 487-490, 2017.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-808953
Biblioteca responsável:
WPRO
ABSTRACT
Objective@#To investigate Oxidative damage effects induced by CdTe Quantum Dots (QDs) in mice.@*Methods@#40 ICR mice were randomly divided into 5 groups one control group (normal saline) ; four CdTe QDs (exposed by intravenous injection of 0.2 ml of CdTe QDs at the concentration of 0、0.5、5.0、50.0 and 500.0 nmol/ml respectively) . After 24 h, the mice were decapitated and the blood was collected for serum biochemically indexes、hematology indexes, the activities of SOD、GSH-Px and the concentration of MDA were all detected.@*Results@#The results showed in the four CdTe QDs exposure groups, the level of CRE、PLT and the concentration of MDA were all significantly lower than those of the control group (P<0.05 or P<0.01) ; the activities GSH-Px in 50.0 and 500.0 nmol/ml CdTe QDs group were significantly higher than those of control group (P<0.01) .@*Conclusion@#It was suggested that CdTe QDs at 0.5 nmol/ml could induce Oxidative damage effects in mice.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2017
Tipo de documento:
Artigo