Synthesis of 1-(4-methylbenzyl)-2-methyl-octahydro-isoquinoline hydrochloride / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 548-550, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-811859
Biblioteca responsável:
WPRO
ABSTRACT
@#1-(4-Methylbenzyl)-2-methyl-octahydro-isoquinoline hydrochloride(1)is the key intermediate to prepare a new type of antitussives agent phosphate dimemorfan. 4-methyl-phenylacetic acid as a raw materials, was chlorinated with thionyl chloride to obtain 4-methyl-phenylacetyl chloride, followed by reaction with 2-cyclohexenyl amine, then cyclization, reduction, methylation and salt formation by HCl were taken out to give the desired product 1. The total yield is 54%, and the purity is greater than 98%. This synthetic process is characterized with available raw materials, simple in operation with high yield and purity, and suitable for large-scale production.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of China Pharmaceutical University
Ano de publicação:
2016
Tipo de documento:
Artigo