Progress in the study of macrophage activation and ulcerative colitis from the Notch/NF-κB/NLRP3 signaling pathway / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1174-1178, 2019.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-813033
Biblioteca responsável:
WPRO
ABSTRACT
Ulcerative colitis is an intestinal inflammatory disease characterized by diarrhea, abdominal pain and purulent stool. Uncontrolled inflammation caused by macrophage hyper-activation is an important cause of ulcerative colitis. Therefore, inhibiting macrophage hyper-activation is an effective way to treat ulcerative colitis. Notch signaling pathway is involved in regulating the immune response of macrophages and promoting inflammation. NF-κB signaling pathway is the "star pathway" involved in inflammation. NLRP3 inflammatory body is involved in the activation of macrophages. Notch, NF-κB and NLRP3 inflammatory bodies constitute the upstream and downstream signal pathways in the existing immune inflammatory diseases. Notch signal pathway can regulate the activation of macrophage via NF-κB/NLRP3 inflammatory body signaling pathway.
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Diarreia
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transdução de Sinais
/
Colite Ulcerativa
/
Citocinas
/
NF-kappa B
/
Receptores Notch
/
Proteína 3 que Contém Domínio de Pirina da Família NLR
/
Ativação de Macrófagos
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2019
Tipo de documento:
Artigo